Gαq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
RJ Rojas, ME Yohe, S Gershburg, T Kawano… - Journal of biological …, 2007 - ASBMB
The coordinated cross-talk from heterotrimeric G proteins to Rho GTPases is essential
during a variety of physiological processes. Emerging data suggest that members of the Gα
12/13 and Gα q/11 families of heterotrimeric G proteins signal downstream to RhoA via
distinct pathways. Although studies have elucidated mechanisms governing Gα 12/13-
mediated RhoA activation, proteins that functionally couple Gα q/11 to RhoA activation have
remained elusive. Recently, the Dbl-family guanine nucleotide exchange factor (GEF) …
during a variety of physiological processes. Emerging data suggest that members of the Gα
12/13 and Gα q/11 families of heterotrimeric G proteins signal downstream to RhoA via
distinct pathways. Although studies have elucidated mechanisms governing Gα 12/13-
mediated RhoA activation, proteins that functionally couple Gα q/11 to RhoA activation have
remained elusive. Recently, the Dbl-family guanine nucleotide exchange factor (GEF) …
