Importance Patients with vascular malformations (VAMs) and vascular overgrowth
syndromes have lower health-related quality of life (HRQoL) attributable to social
stigmatization, poor mental health, severity, and pain. However, the factors that contribute to
this decreased HRQoL are not clear. Objective To perform a systematic review and meta-
analysis of studies that used validated HRQoL instruments to compare the HRQoL of
persons with VAMs with the US general population. Data Sources A comprehensive search …