Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration
D Dormann, C Haass - Molecular and Cellular Neuroscience, 2013 - Elsevier
Fused in sarcoma (FUS) is a nuclear DNA/RNA binding protein that regulates different steps
of gene expression, including transcription, splicing and mRNA transport. FUS has been
implicated in neurodegeneration, since mutations in FUS cause familial amyotrophic lateral
sclerosis (ALS-FUS) and lead to the cytosolic deposition of FUS in the brain and spinal cord
of ALS-FUS patients. Moreover, FUS and two related proteins of the same protein family
(FET family) are co-deposited in cytoplasmic inclusions in a subset of patients with …
of gene expression, including transcription, splicing and mRNA transport. FUS has been
implicated in neurodegeneration, since mutations in FUS cause familial amyotrophic lateral
sclerosis (ALS-FUS) and lead to the cytosolic deposition of FUS in the brain and spinal cord
of ALS-FUS patients. Moreover, FUS and two related proteins of the same protein family
(FET family) are co-deposited in cytoplasmic inclusions in a subset of patients with …