Normal graft function after pig-to-human kidney xenotransplant
JE Locke, V Kumar, D Anderson, PM Porrett - JAMA surgery, 2023 - jamanetwork.com
Methods| In this case series, persons aged 18 years or older declared brain dead whose
families provided informed consent for study participation were eligible for study entry after
all organ donation options for transplant were exhausted. The decedent received
cardiopulmonary support in a critical care setting for the duration of the study. Porcine donor
animals with 10 gene modifications, including 4 gene knockdowns and knockouts (GTKO,
CMAH, B4GALNT2, GHR) and 6 human transgene insertions (CD46, CD55, CD47, THBD …
families provided informed consent for study participation were eligible for study entry after
all organ donation options for transplant were exhausted. The decedent received
cardiopulmonary support in a critical care setting for the duration of the study. Porcine donor
animals with 10 gene modifications, including 4 gene knockdowns and knockouts (GTKO,
CMAH, B4GALNT2, GHR) and 6 human transgene insertions (CD46, CD55, CD47, THBD …