[HTML][HTML] Genetic inhibition of APOL1 pore-forming function prevents APOL1-mediated kidney disease
Background African Americans are at increased risk for nondiabetic CKD in part due to HR
variants in the APOL1 gene. Methods We tested whether a different APOL1 variant, p.
N264K, modified the association between APOL1 HR genotypes (two copies of G1/G2) and
CKD in a cross-sectional analysis of 121,492 participants of African ancestry from the MVP.
We replicated our findings in the Vanderbilt University Biobank (n= 14,386) and National
Institutes of Health All of Us (n= 14,704). Primary outcome was CKD and secondary outcome …
variants in the APOL1 gene. Methods We tested whether a different APOL1 variant, p.
N264K, modified the association between APOL1 HR genotypes (two copies of G1/G2) and
CKD in a cross-sectional analysis of 121,492 participants of African ancestry from the MVP.
We replicated our findings in the Vanderbilt University Biobank (n= 14,386) and National
Institutes of Health All of Us (n= 14,704). Primary outcome was CKD and secondary outcome …