APOL1 risk variants impair multiple mitochondrial pathways in a metabolomics analysis
L Ma, ND Palmer, YA Choi, M Murea, JA Snipes… - Kidney360, 2020 - journals.lww.com
Background Kidney risk variants (KRVs) in the APOL1 gene are associated with
mitochondrial dysfunction. However, the molecular spectrum of metabolites affected by the
G1 and G2 KRVs, and the downstream mitochondrial pathways they affect, remain unknown.
Methods We performed a metabolomics analysis using HEK293 Tet-on cells conditionally
expressing APOL1 G0, G1, and G2 KRVs to determine the patterns of metabolites and
pathways potentially involved in nephropathy. The Welch two-sample t test, matched-pairs t …
mitochondrial dysfunction. However, the molecular spectrum of metabolites affected by the
G1 and G2 KRVs, and the downstream mitochondrial pathways they affect, remain unknown.
Methods We performed a metabolomics analysis using HEK293 Tet-on cells conditionally
expressing APOL1 G0, G1, and G2 KRVs to determine the patterns of metabolites and
pathways potentially involved in nephropathy. The Welch two-sample t test, matched-pairs t …