Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis
A Sipos, SL Vargas, I Toma, F Hanner… - Journal of the …, 2009 - journals.lww.com
In the renal tubule, ATP is an important regulator of salt and water reabsorption, but the
mechanism of ATP release is unknown. Several connexin (Cx) isoforms form
mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional
apical membrane of cells in the distal nephron and tested whether Cx30 participates in
physiologically important release of ATP. We dissected, partially split open, and
microperfused cortical collecting ducts from wild-type and Cx30-deficient mice in vitro. We …
mechanism of ATP release is unknown. Several connexin (Cx) isoforms form
mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional
apical membrane of cells in the distal nephron and tested whether Cx30 participates in
physiologically important release of ATP. We dissected, partially split open, and
microperfused cortical collecting ducts from wild-type and Cx30-deficient mice in vitro. We …