[HTML][HTML] Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress
SM Swain, RA Liddle - Journal of Biological Chemistry, 2021 - ASBMB
The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial
cells. However, the mechanism by which Piezo1 and TRPV4 channels execute the same
function is poorly understood. Here we demonstrate that Piezo1 regulates TRPV4 channel
activation in endothelial cells and that Piezo1-mediated TRPV4 channel opening is a
function of the strength and duration of fluid shear stress. We first confirmed that either fluid …
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial
cells. However, the mechanism by which Piezo1 and TRPV4 channels execute the same
function is poorly understood. Here we demonstrate that Piezo1 regulates TRPV4 channel
activation in endothelial cells and that Piezo1-mediated TRPV4 channel opening is a
function of the strength and duration of fluid shear stress. We first confirmed that either fluid …