Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice
A Michalon, A Bruns, C Risterucci, M Honer… - Biological …, 2014 - Elsevier
Background Fragile X syndrome (FXS) is the most common genetic cause for intellectual
disability. Fmr1 knockout (KO) mice are an established model of FXS. Chronic
pharmacological inhibition of metabotropic glutamate receptor 5 (mGlu5) in these mice
corrects multiple molecular, physiological, and behavioral phenotypes related to patients'
symptoms. To better understand the pathophysiology of FXS and the effect of treatment,
brain activity was analyzed using functional magnetic resonance imaging in relation to …
disability. Fmr1 knockout (KO) mice are an established model of FXS. Chronic
pharmacological inhibition of metabotropic glutamate receptor 5 (mGlu5) in these mice
corrects multiple molecular, physiological, and behavioral phenotypes related to patients'
symptoms. To better understand the pathophysiology of FXS and the effect of treatment,
brain activity was analyzed using functional magnetic resonance imaging in relation to …