Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet
S Kume, T Uzu, S Araki, T Sugimoto… - Journal of the …, 2007 - journals.lww.com
Metabolic syndrome is associated with increased risk of chronic kidney disease, and the
renal injury in patients with metabolic syndrome may be a result of altered renal lipid
metabolism. We fed wild-type or insulin-sensitive heterozygous peroxisome proliferator–
activated receptor γ–deficient (PPARγ+/−) mice a high-fat diet for 16 weeks. In wild-type
mice, this diet induced core features of metabolic syndrome, subsequent renal lipid
accumulation, and renal injury including glomerulosclerosis, interstitial fibrosis, and …
renal injury in patients with metabolic syndrome may be a result of altered renal lipid
metabolism. We fed wild-type or insulin-sensitive heterozygous peroxisome proliferator–
activated receptor γ–deficient (PPARγ+/−) mice a high-fat diet for 16 weeks. In wild-type
mice, this diet induced core features of metabolic syndrome, subsequent renal lipid
accumulation, and renal injury including glomerulosclerosis, interstitial fibrosis, and …