cdc25+ functions as an inducer in the mitotic control of fission yeast
P Russell, P Nurse - Cell, 1986 - cell.com
P Russell, P Nurse
Cell, 1986•cell.comIn the fission yeast S. pombe the c&25+ gene function is required to initiate mitosis. We have
cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis
to initiate at a reduced cell size. This shows that cdc25+ functions as a dosagedependent
inducer in mitotic control, the first such mitotic control element to be specifically identified.
DNA sequencing of the cdc25+ gene has shown that it can encode a protein of MW 67,000.
Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic …
cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis
to initiate at a reduced cell size. This shows that cdc25+ functions as a dosagedependent
inducer in mitotic control, the first such mitotic control element to be specifically identified.
DNA sequencing of the cdc25+ gene has shown that it can encode a protein of MW 67,000.
Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic …
Summary
In the fission yeast S. pombe the c&25+ gene function is required to initiate mitosis. We have cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis to initiate at a reduced cell size. This shows that cdc25+ functions as a dosagedependent inducer in mitotic control, the first such mitotic control element to be specifically identified. DNA sequencing of the cdc25+ gene has shown that it can encode a protein of MW 67,000. Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor weeI+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.
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