Cell cycle and senescence regulation by podocyte histone deacetylase 1 and 2
PXM Rangel, E Cross, C Liu, CE Pedigo… - Journal of the …, 2023 - journals.lww.com
Background Intact expression of podocyte histone deacetylases (HDAC) during
development is essential for maintaining a normal glomerular filtration barrier because of its
role in modulating DNA damage and preventing premature senescence. Methods Germline
podocyte-specific Hdac1 and 2 (Hdac1/2) double-knockout mice were generated to examine
the importance of these enzymes during development. Results Podocyte-specific loss of
Hdac1/2 in mice resulted in severe proteinuria, kidney failure, and collapsing …
development is essential for maintaining a normal glomerular filtration barrier because of its
role in modulating DNA damage and preventing premature senescence. Methods Germline
podocyte-specific Hdac1 and 2 (Hdac1/2) double-knockout mice were generated to examine
the importance of these enzymes during development. Results Podocyte-specific loss of
Hdac1/2 in mice resulted in severe proteinuria, kidney failure, and collapsing …