Mutations of the LMX1B gene cause nail–patella syndrome, a rare autosomal-dominant
disorder affecting the development of the limbs, eyes, brain, and kidneys. The
characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the
development of podocyte foot processes and slit diaphragms, but studies using podocyte-
specific Lmx1b knockout mice have yielded conflicting results regarding the importance of
LMX1B for maintaining podocyte structures. In order to address this question, we generated …