Hypertension and its comorbidities pose a major public health problem associated with
disease-associated factors related to a modern lifestyle, such high salt intake or obesity.
Accumulating evidence has demonstrated that aldosterone and its receptor, the
mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive
hypertension and coexisting cardiovascular and renal injuries. Accordingly, clinical trials
have repetitively shown the promising effects of MR blockers in these diseases. We and …