[HTML][HTML] High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter
The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted
tubule (DCT) plays a critical role in regulating blood pressure (BP) and K+ homeostasis.
During hyperkalemia, reduced NCC phosphorylation and total NCC abundance facilitate
downstream electrogenic K+ secretion and BP reduction. However, the mechanism for the
K+-dependent reduction in total NCC levels is unknown. Here, we show that NCC levels
were reduced in ex vivo renal tubules incubated in a high-K+ medium for 24–48 h. This …
tubule (DCT) plays a critical role in regulating blood pressure (BP) and K+ homeostasis.
During hyperkalemia, reduced NCC phosphorylation and total NCC abundance facilitate
downstream electrogenic K+ secretion and BP reduction. However, the mechanism for the
K+-dependent reduction in total NCC levels is unknown. Here, we show that NCC levels
were reduced in ex vivo renal tubules incubated in a high-K+ medium for 24–48 h. This …