[HTML][HTML] Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter …
The Na-K-2Cl cotransporter (NKCC1) participates in epithelial transport and in cell volume
maintenance by mediating the movement of ions and water across plasma membranes.
Functional studies have previously demonstrated that NKCC1 activity is stimulated by
protein phosphatase 1 (PP1) inhibitors. In this study, we utilized both in vivo (heterologous
cRNA expression in Xenopus laevis oocytes) and in vitro (32 P-phosphorylation assays with
glutathione S-transferase fusion proteins) experiments to determine whether PP1 exerts its …
maintenance by mediating the movement of ions and water across plasma membranes.
Functional studies have previously demonstrated that NKCC1 activity is stimulated by
protein phosphatase 1 (PP1) inhibitors. In this study, we utilized both in vivo (heterologous
cRNA expression in Xenopus laevis oocytes) and in vitro (32 P-phosphorylation assays with
glutathione S-transferase fusion proteins) experiments to determine whether PP1 exerts its …