A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse

L Chen, CL Chou, MA Knepper - Journal of the American Society …, 2021 - journals.lww.com
Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple
proteins from a single gene. Methods A full-length, small-sample RNA-seq protocol profiled
transcriptomes for all 14 renal tubule segments microdissected from mouse kidneys. Results
This study identified> 34,000 transcripts, including 3709 that were expressed in a segment-
specific manner. All data are provided as an online resource (https://esbl. nhlbi. nih …