The effect of WNK4 on the Na+–Cl− cotransporter is modulated by intracellular chloride
S Bazúa-Valenti, M Chávez-Canales… - Journal of the …, 2015 - journals.lww.com
It is widely recognized that the phenotype of familial hyperkalemic hypertension is mainly a
consequence of increased activity of the renal Na+–Cl− cotransporter (NCC) because of
altered regulation by with no–lysine–kinase 1 (WNK1) or WNK4. The effect of WNK4 on
NCC, however, has been controversial because both inhibition and activation have been
reported. It has been recently shown that the long isoform of WNK1 (L-WNK1) is a chloride-
sensitive kinase activated by a low Cl-concentration. Therefore, we hypothesized that WNK4 …
consequence of increased activity of the renal Na+–Cl− cotransporter (NCC) because of
altered regulation by with no–lysine–kinase 1 (WNK1) or WNK4. The effect of WNK4 on
NCC, however, has been controversial because both inhibition and activation have been
reported. It has been recently shown that the long isoform of WNK1 (L-WNK1) is a chloride-
sensitive kinase activated by a low Cl-concentration. Therefore, we hypothesized that WNK4 …