It has been 25 years since the oligometastatic hypothesis was formally defined and nearly a
century since the first published report of an oligometastatic patient being treated with
curative intent. 1, 2 Despite the passage of time, there remains substantial debate regarding
whether the oligometastatic state exists and whether patients benefit from aggressive local
treatment to metastases. 3 Some authors argue that the oligometastatic state is a separate
disease entity (variously defined with upper limits of 1, 3, 5, or 10 metastases) and that such …