Evaluation of safety of stereotactic body radiotherapy for the treatment of patients with multiple metastases: findings from the NRG-BR001 phase 1 trial
S Chmura, KA Winter, C Robinson, TM Pisansky… - JAMA …, 2021 - jamanetwork.com
Importance Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to
improve survival and is increasingly used. Little evidence supports its safe use to treat
patients with multiple metastases. Objective To establish safety of SBRT dose schedules in
patients with 3 to 4 metastases or 2 metastases in close proximity to each other. Design,
Setting, and Participants This phase 1 trial opened on August 4, 2014, and closed to accrual
on March 20, 2018. Metastases to 7 anatomic locations were included: bone/osseous (BO) …
improve survival and is increasingly used. Little evidence supports its safe use to treat
patients with multiple metastases. Objective To establish safety of SBRT dose schedules in
patients with 3 to 4 metastases or 2 metastases in close proximity to each other. Design,
Setting, and Participants This phase 1 trial opened on August 4, 2014, and closed to accrual
on March 20, 2018. Metastases to 7 anatomic locations were included: bone/osseous (BO) …