Memory T cells are fundamental to maintain immune surveillance of the human body. During
the past decade, it has become apparent that non-recirculating resident memory T cells
(TRMs) form a first line memory response in tissues to tackle re-infections. The fact that
TRMs are essential for local immunity highlights the therapeutic potential of targeting this
population against tumors and infections. However, similar to other immune subsets, TRMs
are heterogenous and may form distinct effector populations with unique functions at diverse …