Immune or brain proinflammatory signaling has been linked to some of the behavioral
effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent
models, and ethanol intake activates the immune system in multiple models. This
bidirectional link raises the possibility that consumption increases immune signaling, which
in turn further increases consumption in a feed-forward cycle. Data from animal and human
studies provide overlapping support for the involvement of immune-related genes and …