High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking
JC Crabbe, AR Ozburn, P Metten… - Pharmacology …, 2017 - Elsevier
Background There is a serious public health need for better understanding of alcohol use
disorder disease mechanisms and for improved treatments. At this writing, only three drugs
are approved by the Food and Drug Administration as medications to treat alcohol use
disorders–disulfiram, naltrexone, and acamprosate. Binge drinking is a form of abusive
alcohol drinking defined by the NIAAA as a drinking to blood alcohol levels (BALs)> 0.08%
during a period of approximately 2 h. To model genetic risk for binge-like drinking, we have …
disorder disease mechanisms and for improved treatments. At this writing, only three drugs
are approved by the Food and Drug Administration as medications to treat alcohol use
disorders–disulfiram, naltrexone, and acamprosate. Binge drinking is a form of abusive
alcohol drinking defined by the NIAAA as a drinking to blood alcohol levels (BALs)> 0.08%
during a period of approximately 2 h. To model genetic risk for binge-like drinking, we have …