Effect of hydrocortisone on 21-day mortality or respiratory support among critically ill patients with COVID-19: a randomized clinical trial
PF Dequin, N Heming, F Meziani, G Plantefève… - Jama, 2020 - jamanetwork.com
Importance Coronavirus disease 2019 (COVID-19) is associated with severe lung damage.
Corticosteroids are a possible therapeutic option. Objective To determine the effect of
hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.
Design, Setting, and Participants Multicenter randomized double-blind sequential trial
conducted in France, with interim analyses planned every 50 patients. Patients admitted to …
Corticosteroids are a possible therapeutic option. Objective To determine the effect of
hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.
Design, Setting, and Participants Multicenter randomized double-blind sequential trial
conducted in France, with interim analyses planned every 50 patients. Patients admitted to …