[HTML][HTML] SARS-CoV-2 501Y. V2 escapes neutralization by South African COVID-19 donor plasma
Nature medicine, 2021•nature.com
Abstract SARS-CoV-2 501Y. V2 (B. 1.351), a novel lineage of coronavirus causing COVID-
19, contains substitutions in two immunodominant domains of the spike protein. Here, we
show that pseudovirus expressing 501Y. V2 spike protein completely escapes three classes
of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete
escape from neutralization, but not binding, by convalescent plasma. These data highlight
the prospect of reinfection with antigenically distinct variants and foreshadows reduced …
19, contains substitutions in two immunodominant domains of the spike protein. Here, we
show that pseudovirus expressing 501Y. V2 spike protein completely escapes three classes
of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete
escape from neutralization, but not binding, by convalescent plasma. These data highlight
the prospect of reinfection with antigenically distinct variants and foreshadows reduced …
Abstract
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
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