Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2
Background & Aims Inflammatory cell infiltration in the liver is a hallmark of non-alcoholic
steatohepatitis (NASH). However, the pathological events which trigger the infiltration of
inflammatory cells to mediate NASH pathogenesis remains poorly understood. This study
aims to investigate the role of neutrophil-derived lipocalin 2 (LCN2) in mediating the
transition from simple steatosis to NASH. Methods Animal models of NASH were induced by
high fat high cholesterol (HFHC) diet and methionine-and choline-deficient (MCD) diet in …
steatohepatitis (NASH). However, the pathological events which trigger the infiltration of
inflammatory cells to mediate NASH pathogenesis remains poorly understood. This study
aims to investigate the role of neutrophil-derived lipocalin 2 (LCN2) in mediating the
transition from simple steatosis to NASH. Methods Animal models of NASH were induced by
high fat high cholesterol (HFHC) diet and methionine-and choline-deficient (MCD) diet in …