Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial
FM Munoz, NH Bond, M Maccato, P Pinell, HA Hammill… - Jama, 2014 - jamanetwork.com
Importance Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and
acellular pertussis (Tdap) vaccine could prevent infant pertussis. Objective To evaluate the
safety and immunogenicity of Tdap immunization during pregnancy and its effect on infant
responses to diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine. Design,
Setting, and Participants Phase 1-2, randomized, double-blind, placebo-controlled, clinical
trial conducted from 2008 to 2012. Forty-eight pregnant women aged 18 to 45 years …
acellular pertussis (Tdap) vaccine could prevent infant pertussis. Objective To evaluate the
safety and immunogenicity of Tdap immunization during pregnancy and its effect on infant
responses to diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine. Design,
Setting, and Participants Phase 1-2, randomized, double-blind, placebo-controlled, clinical
trial conducted from 2008 to 2012. Forty-eight pregnant women aged 18 to 45 years …