TGF-β-dependent induction of CD4+ CD25+ Foxp3+ Tregs by liver sinusoidal endothelial cells
A Carambia, B Freund, D Schwinge, M Heine… - Journal of …, 2014 - Elsevier
Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) have a profound ability
to control immune responses. We have previously shown that the liver is a major source of
peripherally induced Tregs. Here, we investigate the liver cell types and molecular
mechanisms responsible for hepatic Treg induction. Methods To assess the Treg-inducing
potential of liver resident antigen-presenting cell types, we studied the conversion of Foxp3−
non-Tregs into Foxp3+ Tregs induced by liver dendritic cells (DCs), liver sinusoidal …
to control immune responses. We have previously shown that the liver is a major source of
peripherally induced Tregs. Here, we investigate the liver cell types and molecular
mechanisms responsible for hepatic Treg induction. Methods To assess the Treg-inducing
potential of liver resident antigen-presenting cell types, we studied the conversion of Foxp3−
non-Tregs into Foxp3+ Tregs induced by liver dendritic cells (DCs), liver sinusoidal …
