Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells
Background Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is
characterized by recurrent cutaneous infections, increased serum IgE levels, and severe
atopic disease, including food-induced anaphylaxis. However, the contribution of defects in
CD4+ T cells to disease pathogenesis in these patients has not been thoroughly
investigated. Objective We sought to investigate the phenotype and function of DOCK8 …
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is
characterized by recurrent cutaneous infections, increased serum IgE levels, and severe
atopic disease, including food-induced anaphylaxis. However, the contribution of defects in
CD4+ T cells to disease pathogenesis in these patients has not been thoroughly
investigated. Objective We sought to investigate the phenotype and function of DOCK8 …
