Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with
reducing sugars, such as glucose, and tend to form and accumulate under hyperglycemic
conditions. AGE accumulation alters protein function and has been implicated in the
pathogenesis of many degenerative diseases such as diabetic complications. AGEs have
also been shown to promote the production of pro-inflammatory cytokines, but the roles of
AGEs in inflammasome signaling have not been explored in detail. Here, we present …