Transcriptional regulation by hypoxia inducible factors
VL Dengler, MD Galbraith… - Critical reviews in …, 2014 - Taylor & Francis
VL Dengler, MD Galbraith, JM Espinosa
Critical reviews in biochemistry and molecular biology, 2014•Taylor & FrancisThe cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular
mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and
organismal response to hypoxia. We discuss here how the various HIF polypeptides, their
posttranslational modifications, binding partners and transcriptional cofactors affect RNA
polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular
mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and
organismal response to hypoxia. We discuss here how the various HIF polypeptides, their
posttranslational modifications, binding partners and transcriptional cofactors affect RNA
polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
Abstract
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
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