Matrilin-2, a large, oligomeric matrix protein, is expressed by a great variety of cells and forms fibrillar networks

D Piecha, S Muratoglu, M Mörgelin, N Hauser… - Journal of Biological …, 1999 - ASBMB
Matrilin-2 is a member of the protein superfamily with von Willebrand factor type A-like
modules. Mouse matrilin-2 cDNA fragments were expressed in 293-EBNA cells, and the
protein was purified, characterized, and used to immunize rabbits. The affinity-purified
antiserum detects matrilin-2 in dense and loose connective tissue structures, subepithelial
connective tissue of the skin and digestive tract, specialized cartilages, and blood vessel
walls. In situ hybridization of 35 S-labeled riboprobes localizes the matrilin-2 mRNA to …