[HTML][HTML] T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes
DK Chu, Z Mohammed-Ali, R Jiménez-Saiz… - Mucosal …, 2014 - Elsevier
Intestinal T helper type 2 (Th2) immunity in food allergy results in IgG1 and IgE production,
and antigen re-exposure elicits responses such as anaphylaxis and eosinophilic
inflammation. Although interleukin-4 (IL-4) is critically required for allergic sensitization, the
source and control of IL-4 during the initiation of Th2 immunity in vivo remains unclear. Non-
intestinal and non-food allergy systems have suggested that natural killer-like T (NKT) or γδ
T-cell innate lymphocytes can supply the IL-4 required to induce Th2 polarization. Group 2 …
and antigen re-exposure elicits responses such as anaphylaxis and eosinophilic
inflammation. Although interleukin-4 (IL-4) is critically required for allergic sensitization, the
source and control of IL-4 during the initiation of Th2 immunity in vivo remains unclear. Non-
intestinal and non-food allergy systems have suggested that natural killer-like T (NKT) or γδ
T-cell innate lymphocytes can supply the IL-4 required to induce Th2 polarization. Group 2 …
