Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
A Gentilini, K Rombouts, S Galastri, A Caligiuri… - Journal of …, 2012 - Elsevier
BACKGROUNDS & AIMS: Cholangiocarcinoma (CCA) is highly fatal because of early
invasion, widespread metastasis, and lack of an effective therapy. Migration, invasion, and
metastasis of CCA cells are modulated by signals received from stromal cells. The SDF-1–
CXCR4 axis emerges as a pivotal regulator of migration and survival of different tumor cells.
The aim of the present study was to characterize the interaction between CCA cells and
human hepatic stellate cells (hHSC) focusing on the role of SDF-1. METHODS: The …
invasion, widespread metastasis, and lack of an effective therapy. Migration, invasion, and
metastasis of CCA cells are modulated by signals received from stromal cells. The SDF-1–
CXCR4 axis emerges as a pivotal regulator of migration and survival of different tumor cells.
The aim of the present study was to characterize the interaction between CCA cells and
human hepatic stellate cells (hHSC) focusing on the role of SDF-1. METHODS: The …
