Aging, antagonistic pleiotropy and fibrotic disease
VJ Thannickal - The international journal of biochemistry & cell biology, 2010 - Elsevier
The international journal of biochemistry & cell biology, 2010•Elsevier
Tissue fibrosis is most often referred to in its pathological context and is a major cause of
progressive organ failure and death. Here, we consider fibrosis as an evolutionarily
conserved, adaptive tissue response to injury. The role of NADPH oxidase 4 (Nox4) as a
novel pro-fibrogenic mediator is highlighted. The concept that Nox4 may function as an
antagonistically pleiotropic gene in age-associated fibrotic disorders is discussed.
progressive organ failure and death. Here, we consider fibrosis as an evolutionarily
conserved, adaptive tissue response to injury. The role of NADPH oxidase 4 (Nox4) as a
novel pro-fibrogenic mediator is highlighted. The concept that Nox4 may function as an
antagonistically pleiotropic gene in age-associated fibrotic disorders is discussed.
Tissue fibrosis is most often referred to in its pathological context and is a major cause of progressive organ failure and death. Here, we consider fibrosis as an evolutionarily conserved, adaptive tissue response to injury. The role of NADPH oxidase 4 (Nox4) as a novel pro-fibrogenic mediator is highlighted. The concept that Nox4 may function as an antagonistically pleiotropic gene in age-associated fibrotic disorders is discussed.
Elsevier
