Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length …
M Walther, FM Thompson, S Dunachie… - Infection and …, 2006 - Am Soc Microbiol
Infection and immunity, 2006•Am Soc Microbiol
Heterologous prime-boost immunization with DNA and various recombinant poxviruses
encoding malaria antigens is capable of inducing strong cell-mediated immune responses
and partial protection in human sporozoite challenges. Here we report a series of trials
assessing recombinant fowlpox virus and modified vaccinia virus Ankara encoding the
Plasmodium falciparum circumsporozoite protein in various prime-boost combinations,
doses, and application routes. For the first time, these vaccines were administered …
encoding malaria antigens is capable of inducing strong cell-mediated immune responses
and partial protection in human sporozoite challenges. Here we report a series of trials
assessing recombinant fowlpox virus and modified vaccinia virus Ankara encoding the
Plasmodium falciparum circumsporozoite protein in various prime-boost combinations,
doses, and application routes. For the first time, these vaccines were administered …
Abstract
Heterologous prime-boost immunization with DNA and various recombinant poxviruses encoding malaria antigens is capable of inducing strong cell-mediated immune responses and partial protection in human sporozoite challenges. Here we report a series of trials assessing recombinant fowlpox virus and modified vaccinia virus Ankara encoding the Plasmodium falciparum circumsporozoite protein in various prime-boost combinations, doses, and application routes. For the first time, these vaccines were administered intramuscularly and at doses of up to 5 × 108 PFU. Vaccines containing this antigen proved safe and induced modest immune responses but showed no evidence of efficacy in a sporozoite challenge.
American Society for Microbiology