[PDF][PDF] Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice
I Petermann, C Mayer, J Stypmann… - The FASEB …, 2006 - academia.edu
I Petermann, C Mayer, J Stypmann, ML Biniossek, DJ Tobin, MA Engelen, T Dandekar…
The FASEB Journal, 2006•academia.eduCathepsin L (CTSL) belongs to the papain-like family of lysosomal cysteine proteases.
Unlike other cathepsin-deficient animals, CTSL knockout mice show a marked dilated
cardiomyopathy (DCM) at 1 yr of age. The present study was initiated to investigate the
pathogenic sequence that occurs in the heart of ctsl/mice. Specifically, we aimed to establish
the time course of disease progression and to identify the cell biological processes that are
altered by CTSL deficiency in the myocardium.
Unlike other cathepsin-deficient animals, CTSL knockout mice show a marked dilated
cardiomyopathy (DCM) at 1 yr of age. The present study was initiated to investigate the
pathogenic sequence that occurs in the heart of ctsl/mice. Specifically, we aimed to establish
the time course of disease progression and to identify the cell biological processes that are
altered by CTSL deficiency in the myocardium.
Cathepsin L (CTSL) belongs to the papain-like family of lysosomal cysteine proteases. Unlike other cathepsin-deficient animals, CTSL knockout mice show a marked dilated cardiomyopathy (DCM) at 1 yr of age. The present study was initiated to investigate the pathogenic sequence that occurs in the heart of ctsl/mice. Specifically, we aimed to establish the time course of disease progression and to identify the cell biological processes that are altered by CTSL deficiency in the myocardium.
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