[HTML][HTML] Major role of cathepsin L for producing the peptide hormones ACTH, β-endorphin, and α-MSH, illustrated by protease gene knockout and expression
L Funkelstein, T Toneff, C Mosier, SR Hwang… - Journal of biological …, 2008 - ASBMB
The pituitary hormones adrenocorticotropic hormone (ACTH), β-endorphin, and α-
melanocyte stimulating hormone (α-MSH) are synthesized by proteolytic processing of their
common proopiomelanocortin (POMC) precursor. Key findings from this study show that
cathepsin L functions as a major proteolytic enzyme for the production of POMC-derived
peptide hormones in secretory vesicles. Specifically, cathepsin L knock-out mice showed
major decreases in ACTH, β-endorphin, and α-MSH that were reduced to 23, 18, and 7! of …
melanocyte stimulating hormone (α-MSH) are synthesized by proteolytic processing of their
common proopiomelanocortin (POMC) precursor. Key findings from this study show that
cathepsin L functions as a major proteolytic enzyme for the production of POMC-derived
peptide hormones in secretory vesicles. Specifically, cathepsin L knock-out mice showed
major decreases in ACTH, β-endorphin, and α-MSH that were reduced to 23, 18, and 7! of …