Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents
Oxytocin (OT) and vasopressin (AVP) mediate their biological actions by acting on four
known receptors: The OT (uterine) and the AVP V 1a (vasopressor), V 1b (pituitary), V 2
(renal) receptors and a fifth putative AVP V 1c?(vasodilating) receptor. This presentation will
summarize some highlights of the recent progress, in the design and synthesis of selective
peptide agonists, antagonists, radioiodinated ligands, fluorescent ligands and bivalent
ligands for these receptors. Here we present published and unpublished pharmacological …
known receptors: The OT (uterine) and the AVP V 1a (vasopressor), V 1b (pituitary), V 2
(renal) receptors and a fifth putative AVP V 1c?(vasodilating) receptor. This presentation will
summarize some highlights of the recent progress, in the design and synthesis of selective
peptide agonists, antagonists, radioiodinated ligands, fluorescent ligands and bivalent
ligands for these receptors. Here we present published and unpublished pharmacological …