[HTML][HTML] BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation
L Haughn, RG Hawley, DK Morrison… - Journal of Biological …, 2003 - ASBMB
Differentiation of hematopoietic cells from multipotential progenitors is regulated by multiple
growth factors and cytokines. A prominent feature of these soluble factors is promotion of cell
survival, in part mediated by expression of either of the anti-apoptotic proteins, BCL-2 and
BCL-X L. The complex expression pattern of these frequently redundant survival factors
during hematopoiesis may indicate a role in lineage determination. To investigate the latter
possibility, we analyzed factor-dependent cell-Patersen (FDCP)-Mix multipotent progenitor …
growth factors and cytokines. A prominent feature of these soluble factors is promotion of cell
survival, in part mediated by expression of either of the anti-apoptotic proteins, BCL-2 and
BCL-X L. The complex expression pattern of these frequently redundant survival factors
during hematopoiesis may indicate a role in lineage determination. To investigate the latter
possibility, we analyzed factor-dependent cell-Patersen (FDCP)-Mix multipotent progenitor …