[HTML][HTML] Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest
CD Scatena, ZA Stewart, D Mays, LJ Tang… - Journal of Biological …, 1998 - ASBMB
There is increasing evidence that prolonged mitotic arrest initiates apoptosis; however, little
is known about the signaling pathways involved. Several studies have associated
deregulated Cdc2 activity with apoptosis. Herein, we report that the anti-apoptotic protein,
Bcl-2, undergoes cell cycle-dependent phosphorylation during mitosis when there is
elevated Cdc2 activity. We found that paclitaxel (Taxol®) treatment of epithelial tumor cells
induced a prolonged mitotic arrest, elevated levels of mitotic kinase activity …
is known about the signaling pathways involved. Several studies have associated
deregulated Cdc2 activity with apoptosis. Herein, we report that the anti-apoptotic protein,
Bcl-2, undergoes cell cycle-dependent phosphorylation during mitosis when there is
elevated Cdc2 activity. We found that paclitaxel (Taxol®) treatment of epithelial tumor cells
induced a prolonged mitotic arrest, elevated levels of mitotic kinase activity …