[HTML][HTML] Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells: role in activation of the type A natriuretic peptide …
S Chen, L Cao, HD Intengan, M Humphreys… - Journal of Biological …, 2002 - ASBMB
Previously, we showed that increased extracellular tonicity promotes increased type A
natriuretic peptide receptor (NPR-A) expression through a p38 MAPKβ pathway in inner
medullary collecting duct cells. The endothelial and inducible nitric-oxide synthase (eNOS
and iNOS respectively) genes are also expressed in this nephron segment and are thought
to play a role in regulating urinary sodium concentration. We sought to determine whether
changes in tonicity might regulate NOS gene expression, and if so, whether these latter …
natriuretic peptide receptor (NPR-A) expression through a p38 MAPKβ pathway in inner
medullary collecting duct cells. The endothelial and inducible nitric-oxide synthase (eNOS
and iNOS respectively) genes are also expressed in this nephron segment and are thought
to play a role in regulating urinary sodium concentration. We sought to determine whether
changes in tonicity might regulate NOS gene expression, and if so, whether these latter …