[HTML][HTML] Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct: a requirement for p38 MAPK
S Chen, DG Gardner - Journal of Biological Chemistry, 2002 - ASBMB
In the inner medullary collecting duct of the terminal nephron, the type A natriuretic peptide
receptor (NPR-A) plays a major role in determining urinary sodium content. This nephron
segment, by virtue of its medullary location, is subject to very high levels of extracellular
tonicity. We have examined the ability of medium tonicity to regulate the activity and
expression of this receptor in cultured rat inner medullary collecting duct cells. We found that
NaCl (75 mm) and sucrose (150 mm), but not urea (150 mm), increased natriuretic peptide …
receptor (NPR-A) plays a major role in determining urinary sodium content. This nephron
segment, by virtue of its medullary location, is subject to very high levels of extracellular
tonicity. We have examined the ability of medium tonicity to regulate the activity and
expression of this receptor in cultured rat inner medullary collecting duct cells. We found that
NaCl (75 mm) and sucrose (150 mm), but not urea (150 mm), increased natriuretic peptide …