Tonicity responsive enhancer binding protein (TonEBP) is the transcription factor that
regulates tonicity responsive expression of proteins that catalyze cellular accumulation of
compatible osmolytes. In cultured MDCK cells, hypertonicity stimulates the activity of
TonEBP via a combination of increased protein abundance and increased nuclear
localization. For investigating regulation of TonEBP in the kidney, rats were subjected to
water loading or dehydration. Water loading lowered urine osmolality and mRNA expression …