Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells
U Hasler, US Jeon, JA Kim, D Mordasini… - Journal of the …, 2006 - journals.lww.com
Tonicity-responsive enhancer binding protein (TonEBP) plays a key role in protecting renal
cells from hypertonic stress by stimulating transcription of specific genes. Under hypertonic
conditions, TonEBP activity is enhanced via increased nuclear translocation, transactivation,
and abundance. It was reported previously that hypertonicity exerted a dual, time-dependent
effect on vasopressin-inducible aquaporin-2 (AQP2) expression in immortalized mouse
collecting duct principal cells (mpkCCD cl4). Whereas AQP2 abundance decreased after 3 h …
cells from hypertonic stress by stimulating transcription of specific genes. Under hypertonic
conditions, TonEBP activity is enhanced via increased nuclear translocation, transactivation,
and abundance. It was reported previously that hypertonicity exerted a dual, time-dependent
effect on vasopressin-inducible aquaporin-2 (AQP2) expression in immortalized mouse
collecting duct principal cells (mpkCCD cl4). Whereas AQP2 abundance decreased after 3 h …