Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse
HK Yap, WAI CHEUNG, B MURUGASU… - Journal of the …, 1999 - journals.lww.com
Idiopathic nephrotic syndrome of childhood is thought to be associated with T lymphocyte
dysfunction often triggered by viral infections, with the production of circulating factor (s)
resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2
pattern of cytokine synthesis in this disease, this study examined the mRNA expression of
interleukin-2 (IL-2), interferon-γ, IL-4, and IL-13 from CD4+ and CD8+ T cells in steroid-
responsive nephrotic patients in relapse and remission. Fifty-five children with steroid …
dysfunction often triggered by viral infections, with the production of circulating factor (s)
resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2
pattern of cytokine synthesis in this disease, this study examined the mRNA expression of
interleukin-2 (IL-2), interferon-γ, IL-4, and IL-13 from CD4+ and CD8+ T cells in steroid-
responsive nephrotic patients in relapse and remission. Fifty-five children with steroid …