[HTML][HTML] IQGAP1 promotes cell motility and invasion
JM Mataraza, MW Briggs, Z Li, A Entwistle… - Journal of Biological …, 2003 - ASBMB
The dynamic processes of cell migration and invasion are largely coordinated by Rho family
GTPases. The scaffolding protein IQGAP1 binds to Cdc42, increasing the amount of active
Cdc42 both in vitro and in cells. Here we show that overexpression of IQGAP1 in
mammalian cells enhances cell migration in a Cdc42-and Rac1-dependent manner.
Importantly, cell motility was significantly decreased both by knock down of endogenous
IQGAP1 using small interfering RNA and by transfection of a dominant negative IQGAP1 …
GTPases. The scaffolding protein IQGAP1 binds to Cdc42, increasing the amount of active
Cdc42 both in vitro and in cells. Here we show that overexpression of IQGAP1 in
mammalian cells enhances cell migration in a Cdc42-and Rac1-dependent manner.
Importantly, cell motility was significantly decreased both by knock down of endogenous
IQGAP1 using small interfering RNA and by transfection of a dominant negative IQGAP1 …