Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact.
IT Valyi-Nagy, G Hirka, PJ Jensen, IM Shih… - … ; a journal of technical …, 1993 - europepmc.org
Laboratory investigation; a journal of technical methods and pathology, 1993•europepmc.org
Background Melanocytes in the normal human epidermis are generally dendritic and neither
proliferate nor express melanoma-associated antigens. In culture, on the other hand,
melanocytes are bi-to tripolar, proliferate with 2 to 4 day doubling times, and express
melanoma-associated antigens. This observation prompted us to investigate the regulatory
role of keratinocytes for growth, morphology, and antigen expression of melanocytes.
proliferate nor express melanoma-associated antigens. In culture, on the other hand,
melanocytes are bi-to tripolar, proliferate with 2 to 4 day doubling times, and express
melanoma-associated antigens. This observation prompted us to investigate the regulatory
role of keratinocytes for growth, morphology, and antigen expression of melanocytes.
Background
Melanocytes in the normal human epidermis are generally dendritic and neither proliferate nor express melanoma-associated antigens. In culture, on the other hand, melanocytes are bi-to tripolar, proliferate with 2 to 4 day doubling times, and express melanoma-associated antigens. This observation prompted us to investigate the regulatory role of keratinocytes for growth, morphology, and antigen expression of melanocytes.
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